Osterud B
Haemostasis. 1979;8(3-5):324-31. doi: 10.1159/000214322.
The effect of collagen on isolated platelets, platelet-rich plasma and whole blood has been studied. Collagen failed to generate factor XIa-like activity in mixtures of isolated platelets, collagen and Ca++. Moreover, collagen added to whole blood or platelet-rich plasma containing 125I-factor IX and Ca++, also failed to form cleaved (activated) factor IX. In preliminary studies, lysed endothelial cells were found to enhance the formation of factor Xa and thrombin and to induce cleavage of 125I-factor IX in normal plasma, factor XII and factor-XI-deficient plasma even in the presence of antibody to tissue factor.
已对胶原蛋白对分离的血小板、富血小板血浆和全血的作用进行了研究。在分离的血小板、胶原蛋白和钙离子的混合物中，胶原蛋白未能产生类似因子XIa的活性。此外，将胶原蛋白添加到含有125I-因子IX和钙离子的全血或富血小板血浆中，也未能形成裂解（活化）的因子IX。在初步研究中，发现裂解的内皮细胞可增强因子Xa和凝血酶的形成，并在正常血浆、因子XII和因子XI缺乏的血浆中诱导125I-因子IX的裂解，即使存在针对组织因子的抗体时也是如此。
