5-N-乙酰-D-神经氨酸异头物乙基酮糖苷的合成。
Synthesis of anomeric ethyl ketosides of 5-N-acetyl-D-neuraminic acid.
作者信息
Eschenfelder V, Brossmer R
出版信息
Hoppe Seylers Z Physiol Chem. 1979 Sep;360(9):1253-6. doi: 10.1515/bchm2.1979.360.2.1253.
PMID:511115
Abstract
The syntheses of anomeric ethyl ketosides of 5-N-acetyl-D-neuraminic acid are described. The alpha-anomer prepared by a modified Koenigs-Knorr procedure starting from acetochloroneuraminic acid is quantitatively cleaved by Vibrio cholerae neuraminidase. Proton-catalyzed reaction of 5-N-acetyl-D-neuraminic acid with ethanol yields the beta-anomer.
摘要
描述了5-N-乙酰-D-神经氨酸异头乙基酮糖苷的合成。通过改进的柯尼希斯-克诺尔方法从乙酰氯神经氨酸开始制备的α-异头物被霍乱弧菌神经氨酸酶定量裂解。5-N-乙酰-D-神经氨酸与乙醇的质子催化反应产生β-异头物。
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