Dupuy M, Cherruault Y
Int J Biomed Comput. 1979 Sep;10(5):383-99. doi: 10.1016/0020-7101(79)90053-9.
After a short review of the functional anatomy of the kidney, we express the usual hypotheses about the phenomena of reabsorption and filtration in the loop of Henle and the collecting duct. Starting from these hypotheses and the laws of biophysics, we formulate the equations of the model. This model accounts for the great increase in concentration of electrolyte and urea in the loop of Henle, the collecting duct and the interstitium, as we "go down" from the outer medullary area towards the inner areas, the active transportation of sodium in the loop of Henle being limited to the thick ascending limb.
在对肾脏的功能解剖进行简短回顾之后,我们阐述了关于亨利袢和集合管中重吸收与滤过现象的常见假设。从这些假设以及生物物理学定律出发,我们构建了该模型的方程。此模型解释了从外髓区域向内部区域“下行”时,亨利袢、集合管和间质中电解质和尿素浓度的大幅增加,亨利袢中钠的主动转运仅限于髓袢升支粗段。