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6-Chlorochroman-2-carboxylic acids. Synthesis and biological evaluation as antagonists for cholesterol biosynthesis and lipolysis in vitro.

作者信息

Witiak D T, Stratford E S, Nazareth R, Wagner G, Feller D R

出版信息

J Med Chem. 1971 Aug;14(8):758-66. doi: 10.1021/jm00290a021.

DOI:10.1021/jm00290a021
PMID:5114072
Abstract
摘要

相似文献

1
6-Chlorochroman-2-carboxylic acids. Synthesis and biological evaluation as antagonists for cholesterol biosynthesis and lipolysis in vitro.6-氯色满-2-羧酸。作为体外胆固醇生物合成和脂解拮抗剂的合成及生物学评价。
J Med Chem. 1971 Aug;14(8):758-66. doi: 10.1021/jm00290a021.
2
Inhibitory action of -(4-chlorophenoxy)- -methylpropionic acid analogs on cholesterol biosynthesis and lipolysis in vitro.α-(4-氯苯氧基)-α-甲基丙酸类似物对体外胆固醇生物合成及脂肪分解的抑制作用
J Med Chem. 1971 Aug;14(8):754-7. doi: 10.1021/jm00290a020.
3
Hypocholesterolemic indole-2-carboxylic acids.降胆固醇吲哚 -2- 羧酸
J Med Chem. 1972 Jun;15(6):659-62. doi: 10.1021/jm00276a024.
4
[Inhibition of cholesterol biosynthesis by mevalonic acid derivatives].[甲羟戊酸衍生物对胆固醇生物合成的抑制作用]
Biokhimiia. 1971 Jul-Aug;36(4):851-6.
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Glycerol as an inhibitor of cholesterol synthesis.甘油作为胆固醇合成的抑制剂。
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Effect of pyrazole on lipolysis in vitro.吡唑对体外脂肪分解的影响。
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Differential effects of benzodioxane, chroman and dihydrobenzofuran analogs of clofibrate in a Triton hyperlipemic rat model.
Lipids. 1973 Jul;8(7):378-84. doi: 10.1007/BF02531712.
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Inhibition of lipid biosynthesis.脂质生物合成的抑制
Ann N Y Acad Sci. 1968 Mar 26;148(3):631-46. doi: 10.1111/j.1749-6632.1968.tb27737.x.
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Treloxinate and related hypolipidemic 12H-dibenzo(d,g)(1,3)dioxocin-6-carboxylate derivatives.曲洛昔酸及相关的降血脂12H-二苯并(d,g)(1,3)二氧杂环辛-6-羧酸酯衍生物
J Med Chem. 1972 Dec;15(12):1273-8. doi: 10.1021/jm00282a018.
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Inhibition of hepatic cholesterol biosynthesis by 3,5-dihydroxy-3,4,4-trimethylvaleric acid and its site of action.
Arch Biochem Biophys. 1971 Oct;146(2):422-7. doi: 10.1016/0003-9861(71)90144-5.

引用本文的文献

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Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1.2-(对氯苯氧基)丙酸类似物对天然大鼠骨骼肌氯电导及异源表达的CLC-1活性的结构要求
Br J Pharmacol. 2003 Aug;139(7):1255-64. doi: 10.1038/sj.bjp.0705364.
2
Hypolipidemic effects of clofibrate and selected chroman analogs in fasted rats: I. Chow-fed animals.氯贝丁酯及选定色满类似物对禁食大鼠的降血脂作用：I. 喂饲普通饲料的动物。
Lipids. 1981 Dec;16(12):903-11. doi: 10.1007/BF02534996.
3
Antilipidemic activity of 4-oxo-functionalized ethyl 6-chlorochroman-2-carboxylate analogs and a related tricyclic lactone in three rat models.
Lipids. 1981 Jan;16(1):30-6. doi: 10.1007/BF02534918.
4
Hypolipidemic effects of clofibrate and selected chroman analogs in fasted rats: II. High sucrose-fed animals.氯贝丁酯及选定色满类似物对禁食大鼠的降血脂作用：II. 高蔗糖喂养的动物
Lipids. 1983 Jan;18(1):59-67. doi: 10.1007/BF02534692.
5
Differential effects of benzodioxane, chroman and dihydrobenzofuran analogs of clofibrate in a Triton hyperlipemic rat model.
Lipids. 1973 Jul;8(7):378-84. doi: 10.1007/BF02531712.