接受抗惊厥药物治疗的癫痫儿童的钙代谢改变。
Altered calcium metabolism in epileptic children on anticonvulsants.
作者信息
Hunter J, Maxwell J D, Stewart D A, Parsons V, Williams R
出版信息
Br Med J. 1971 Oct 23;4(5781):202-4. doi: 10.1136/bmj.4.5781.202.
Abstract
A survey of 105 epileptic children aged 10-16 years at a residential school who were taking anticonvulsant drugs showed reduced serum calcium levels in 30% and a raised serum alkaline phosphatase in 24%. Urinary D-glucaric acid excretion, a quantitative index of hepatic enzyme induction, was raised in 94% of the children, and statistical analysis showed a significant inverse correlation with the level of serum calcium. These findings give further support for the view that an important factor in the development of the hypocalcaemia and occasional clinical osteomalacia in epileptics on anticonvulsant drugs is an alteration of vitamin-D metabolism in the liver as a result of microsomal enzyme induction. As a consequence there is an increased requirement for vitamin D which may not be met by average intakes in Britain.
摘要
对一所寄宿学校105名10至16岁正在服用抗惊厥药物的癫痫儿童进行的一项调查显示，30%的儿童血清钙水平降低，24%的儿童血清碱性磷酸酶升高。尿D - 葡萄糖醛酸排泄是肝酶诱导的定量指标，94%的儿童该指标升高，统计分析显示其与血清钙水平呈显著负相关。这些发现进一步支持了以下观点：服用抗惊厥药物的癫痫患者发生低钙血症和偶发临床骨软化症的一个重要因素是微粒体酶诱导导致肝脏中维生素D代谢改变。因此，对维生素D的需求增加，而英国的平均摄入量可能无法满足这一需求。
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