γ射线辐照对抗体依赖性淋巴细胞介导的细胞毒性的致敏阶段和效应阶段的差异作用。
The differential effect of gamma irradiation on the sensitizing and effector stages of antibody dependent lymphocyte mediated cytotoxicity.
作者信息
Pudifin D J, Harding B, MacLennan I C
出版信息
Immunology. 1971 Nov;21(5):853-60.
The effect of whole body γ irradiation of donors on the cytotoxic action of spleen cells from specifically sensitized rats towards the xenogeneic Chang cell was studied. The target cells in this model are killed by effector lymphocytes which are triggered into cytotoxic activity by IgG complexed with target cell antigens. A separate population of lymphocytes produces the sensitizing antibody. It was shown that production of sensitizing antibody could not be induced within 16 days after 850 rad whole body irradiation. The cytotoxic effector population, however, despite initial severe depletion, neared complete recovery by this time. The implications of this differential effect are discussed.
研究了对供体进行全身γ照射对特异性致敏大鼠脾细胞针对异种Chang细胞的细胞毒作用的影响。在该模型中，靶细胞被效应淋巴细胞杀死，效应淋巴细胞由与靶细胞抗原复合的IgG触发进入细胞毒活性状态。另一群淋巴细胞产生致敏抗体。结果表明，850拉德全身照射后16天内不能诱导致敏抗体的产生。然而，细胞毒性效应细胞群尽管最初严重耗竭，但此时已接近完全恢复。讨论了这种差异效应的意义。
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