人补体第四成分（C4）在母体和胎儿血浆中的电泳多态性

Bach S, Ruddy S, MacLaren J A, Austen K F

Immunology. 1971 Nov;21(5):869-78.

The polymorphism of the fourth component of complement (C4) as demonstrated by antigen—antibody crossed electrophoresis was used to study paired samples of maternal and cord plasma. Curve analysis was employed to analyse the qualitative and quantitative composition of the C4 patterns. Among the fifty-two paired samples studied, the findings in nine could not be explained by placental passage of C4 from mother to foetus, and evidence for foetal synthesis of C4 was found in five cases. Family studies supported the genetic basis for the electrophoretic polymorphism of C4.

采用抗原 - 抗体交叉电泳所显示的补体第四成分（C4）的多态性，对母婴血浆配对样本进行研究。运用曲线分析来分析C4图谱的定性和定量组成。在所研究的52对配对样本中，9对样本的结果无法用C4从母体经胎盘传递给胎儿来解释，且在5例中发现了胎儿合成C4的证据。家系研究支持了C4电泳多态性的遗传基础。