Collins J C, Harris T R, McKeen C R, Brigham K L
J Appl Physiol Respir Environ Exerc Physiol. 1979 Oct;47(4):792-7. doi: 10.1152/jappl.1979.47.4.792.
Pulmonary edema frequently accompanies acute myocardial infarction (MI). We measured pulmonary arterial (PAP), left atrial (LAP), and aortic pressures (AP),lung lymph flow (QL), and clearance of total serum protein and each of eight protein fractions in five anesthetized sheep before and after coronary artery ligation. After a stable base line of 1 h, ligation produced significant increases in LAP, QL, and clearance of total protein and four protein fractions, but no significant changes in PAP, AP, or lymph-to-plasma total protein concentration ratio (CSL/CSP). Variables returned to pre-MI levels within 2 h after occlusion. The ratio of wet to dry lung weight measured 2 h after ligation was within normal limits. Two sheep in which the time course of postligation LAP was duplicated by left atrial balloon inflation showed no change in QL. The QL changes seen cannot be caused by LAP increase alone without substantial decrease in CSL/CSP. Increased QL with high CSL/CSP is typical of increased lung vascular permeability, which is a plausible explanation of our results.
肺水肿常伴随急性心肌梗死（MI）。我们在五只麻醉绵羊冠状动脉结扎前后测量了肺动脉压（PAP）、左心房压（LAP）和主动脉压（AP）、肺淋巴流量（QL）以及总血清蛋白和八种蛋白组分各自的清除率。在1小时的稳定基线期后，结扎导致LAP、QL以及总蛋白和四种蛋白组分的清除率显著增加，但PAP、AP或淋巴与血浆总蛋白浓度比（CSL/CSP）无显著变化。闭塞后2小时内各项指标恢复到心肌梗死前水平。结扎后2小时测量的肺湿重与干重之比在正常范围内。两只通过左心房球囊充气复制结扎后LAP时间进程的绵羊，其QL无变化。观察到的QL变化不可能仅由LAP升高引起而CSL/CSP不显著降低。CSL/CSP升高时QL增加是肺血管通透性增加的典型表现，这是对我们结果的一个合理的解释。
