来自人κ链的糖肽。

Glycopeptides from human kappa-chains.

作者信息

Milstein C P, Milstein C

出版信息

Biochem J. 1971 Jan;121(2):211-5. doi: 10.1042/bj1210211.

DOI:10.1042/bj1210211

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1176557/

Abstract

Glycopeptides have been isolated from tryptic digests of kappa-type light chains separated from human myeloma proteins obtained from the serum of two patients, Car and Rai. The glycopeptides are derived from the variable region of the chain in both cases, but from different sections. On the basis of homology it is deduced that glycopeptide from Car, kappaI type, is derived from position 25-31 whereas that from Rai, kappaII type, is from position 62-77, their sequences being respectively Ala-Ser-Gln-Asn-Ile-Ser and Phe-Ser-Gly-Ser-Gly-Ser-Gly(Thr,Asp)Phe-Thr-Leu-Asx-Ile-Ser-Arg. The significance of the results is discussed in connexion with the nature of the attachment site of carbohydrate to protein.

摘要

从两名患者（卡尔和拉伊）血清中获得的人骨髓瘤蛋白分离出的κ型轻链的胰蛋白酶消化物中分离出了糖肽。在这两种情况下，糖肽均来自轻链的可变区，但来自不同的区段。根据同源性推断，来自卡尔的κI型糖肽源自第25至31位，而来自拉伊的κII型糖肽源自第62至77位，它们的序列分别为丙氨酸-丝氨酸-谷氨酰胺-天冬酰胺-异亮氨酸-丝氨酸和苯丙氨酸-丝氨酸-甘氨酸-丝氨酸-甘氨酸-丝氨酸-甘氨酸（苏氨酸、天冬氨酸）-苯丙氨酸-苏氨酸-亮氨酸-天冬酰胺/天冬氨酸-异亮氨酸-丝氨酸-精氨酸。结合碳水化合物与蛋白质连接位点的性质对结果的意义进行了讨论。

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Arch Biochem Biophys. 1962 Sep;Suppl 1:174-80.

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Hoppe Seylers Z Physiol Chem. 1957;309(4-6):219-20.

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FEBS Lett. 1969 Mar;2(5):301-304. doi: 10.1016/0014-5793(69)80048-7.

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