Zelman A, White M, Acker K, Neal T, Parsons R, Gisser D
J Dial. 1979;3(2-3):219-35. doi: 10.3109/08860227909063942.
A simple hemodialysis protocol has been developed to permit significant "middle molecule" clearance, yet retain normal low molecular weight clearance. The high flux RP-6 dialyzer has been combined with a single pass dialysate delivery system to provide accurate control of ultrafiltration without resorting to specialized or expensive equipment. By operating the RP-6 in the co-current mode, a simple valve on the dialysate output can be used to regulate ultrafiltration. At QB = 200 ml/min and QD = 500 ml/min, CU = 127 ml/min and CB12 = 56 ml/min at zero ultrafiltration rate; these values increase considerably with ultrafiltration. This protocol offers dialysis centers with standard equipment the opportunity to use high flux membranes in a routine manner.
已开发出一种简单的血液透析方案，以实现显著的“中分子”清除，同时保持正常的低分子量清除率。高通量RP - 6透析器已与单通道透析液输送系统相结合，无需使用专门或昂贵的设备就能精确控制超滤。通过以并流模式操作RP - 6，透析液输出端的一个简单阀门可用于调节超滤。在血流量QB = 200 ml/分钟和透析液流量QD = 500 ml/分钟时，超滤率为零时的超滤量CU = 127 ml/分钟，尿素清除率CB12 = 56 ml/分钟；随着超滤，这些数值会大幅增加。该方案为配备标准设备的透析中心提供了以常规方式使用高通量膜的机会。
