口服叶酸对脑脊液中高香草酸和5-羟吲哚乙酸浓度的影响。

Effect of folic acid by mouth on cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentration.

作者信息

Hunter R, Barnes J, Curzon G, Kantamaneni B D, Duncan C

出版信息

J Neurol Neurosurg Psychiatry. 1971 Oct;34(5):571-5. doi: 10.1136/jnnp.34.5.571.

DOI:10.1136/jnnp.34.5.571

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC493871/

Abstract

Administration of 30 mg folic acid by mouth caused a significant fall in cerebrospinal fluid homovanillic acid concentration in 11 subjects. There was no significant change of 5-hydroxyindoleacetic acid concentration. The fall was less marked in five patients on anticonvulsant medication and failed to reach statistical significance. Neither homovanillic acid nor 5-hydroxyindoleacetic acid concentrations changed significantly when 15 mg folic acid was given in divided dosage for one, two, and four weeks. The effect appeared to be related to the height of serum-folate levels reached and to be independent of cerebrospinal fluid-folate levels, which did not change significantly. Possible mechanisms and their potential therapeutic application are discussed.

摘要

对11名受试者口服30毫克叶酸后，脑脊液中高香草酸浓度显著下降。5-羟吲哚乙酸浓度无显著变化。5名服用抗惊厥药物的患者中，这种下降不太明显，未达到统计学显著性。当分剂量给予15毫克叶酸，持续1周、2周和4周时，高香草酸和5-羟吲哚乙酸浓度均无显著变化。这种作用似乎与所达到的血清叶酸水平高度有关，且独立于脑脊液叶酸水平，后者无显著变化。文中讨论了可能的机制及其潜在的治疗应用。

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