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口服叶酸对脑脊液中高香草酸和5-羟吲哚乙酸浓度的影响。

Effect of folic acid by mouth on cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentration.

作者信息

Hunter R, Barnes J, Curzon G, Kantamaneni B D, Duncan C

出版信息

J Neurol Neurosurg Psychiatry. 1971 Oct;34(5):571-5. doi: 10.1136/jnnp.34.5.571.

DOI:10.1136/jnnp.34.5.571
PMID:5122385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC493871/
Abstract

Administration of 30 mg folic acid by mouth caused a significant fall in cerebrospinal fluid homovanillic acid concentration in 11 subjects. There was no significant change of 5-hydroxyindoleacetic acid concentration. The fall was less marked in five patients on anticonvulsant medication and failed to reach statistical significance. Neither homovanillic acid nor 5-hydroxyindoleacetic acid concentrations changed significantly when 15 mg folic acid was given in divided dosage for one, two, and four weeks. The effect appeared to be related to the height of serum-folate levels reached and to be independent of cerebrospinal fluid-folate levels, which did not change significantly. Possible mechanisms and their potential therapeutic application are discussed.

摘要

对11名受试者口服30毫克叶酸后，脑脊液中高香草酸浓度显著下降。5-羟吲哚乙酸浓度无显著变化。5名服用抗惊厥药物的患者中，这种下降不太明显，未达到统计学显著性。当分剂量给予15毫克叶酸，持续1周、2周和4周时，高香草酸和5-羟吲哚乙酸浓度均无显著变化。这种作用似乎与所达到的血清叶酸水平高度有关，且独立于脑脊液叶酸水平，后者无显著变化。文中讨论了可能的机制及其潜在的治疗应用。

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引用本文的文献

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Drugs and folate metabolism.药物与叶酸代谢
Drugs. 1985 Aug;30(2):145-55. doi: 10.2165/00003495-198530020-00003.

本文引用的文献

1
PURIFICATION AND PROPERTIES OF DIHYDROFOLATE REDUCTASE FROM EHRLICH ASCITES CARCINOMA CELLS.艾氏腹水癌细胞中二氢叶酸还原酶的纯化及性质
Biochemistry. 1965 May;4:839-46. doi: 10.1021/bi00881a007.
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TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS.酪氨酸羟化酶。去甲肾上腺素生物合成的起始步骤。
J Biol Chem. 1964 Sep;239:2910-7.
3
On the occurrence of homovanillic acid in brain and cerebrospinal fluid and its determination by a fluorometric method.关于高香草酸在脑和脑脊液中的存在及其荧光法测定
Life Sci (1962). 1963 Jul(7):448-58. doi: 10.1016/0024-3205(63)90132-2.
4
[The tropical localization and content of noradrenalin and dopamine (3-hydroxytyramine) in the substantia nigra of normal persons and patients with Parkinson's disease].[正常人及帕金森病患者黑质中去甲肾上腺素和多巴胺（3-羟酪胺）的热带定位及含量]
Wien Klin Wochenschr. 1963 May 3;75:309-12.
5
Megaloblastic anaemia due to phenobarbitone; the convulsant action of therapeutic doses of folic acid.苯巴比妥所致巨幼细胞贫血；治疗剂量叶酸的惊厥作用。
Br Med J. 1960 Apr 9;1(5179):1099-102. doi: 10.1136/bmj.1.5179.1099.
6
The decarboxylation of amino acids related to tyrosine and their awakening action in reserpine-treated mice.与酪氨酸相关的氨基酸脱羧作用及其在利血平处理小鼠中的唤醒作用。
J Physiol. 1960 May;151(2):272-84. doi: 10.1113/jphysiol.1960.sp006437.
7
Studies on the folic acid activity of human serum.人体血清叶酸活性的研究。
J Clin Pathol. 1961 Jul;14(4):335-44. doi: 10.1136/jcp.14.4.335.
8
The nature of in vitro hydroxylation of L-tryptophan by brain tissue.脑组织对L-色氨酸的体外羟基化作用的性质。
J Neurochem. 1966 Aug;13(8):643-54. doi: 10.1111/j.1471-4159.1966.tb09872.x.
9
The effect of tropolone on the formation of 3,4-dihydroxyphenylacetic acid and 4-hydroxy-3-methoxyphenylacetic acid in the brain of the mouse.托酚酮对小鼠脑中3,4-二羟基苯乙酸和4-羟基-3-甲氧基苯乙酸形成的影响。
Br J Pharmacol. 1969 May;36(1):107-15. doi: 10.1111/j.1476-5381.1969.tb08308.x.
10
Effect of intraluminal pH on the absorption of pteroylmonoglutamic acid.腔内pH值对蝶酰单谷氨酸吸收的影响。
Br Med J. 1971 Jan 16;1(5741):148-50. doi: 10.1136/bmj.1.5741.148.

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