Hanson R F, Williams G
J Lipid Res. 1971 Nov;12(6):688-91.
Although it has been assumed that the secondary bile acid deoxycholic acid is not rehydroxylated by the human liver, little direct evidence is available to support this assumption. To investigate the metabolism of deoxycholic acid in man, deoxycholic acid-(14)C was given intravenously to two patients with complete external bile fistulas. After hydrolysis of the bile salts and chromatographic separation of bile acids, more than 94% of the radioactivity was found in deoxycholic acid and the remainder was scattered in several small unidentified peaks, none of which was cholic acid. Approximately 85% of deoxycholate was excreted as glycine conjugates and 13% as taurine conjugates in this experiment. No detectable sulfate esters were found. These results indicate that the metabolism of deoxycholic acid in man involves only the reconjugation with glycine and taurine without rehydroxylation to cholic acid or sulfation.
尽管一直认为人体肝脏不会将次级胆汁酸脱氧胆酸再羟化，但几乎没有直接证据支持这一假设。为了研究人体内脱氧胆酸的代谢情况，对两名患有完全性外部胆瘘的患者静脉注射了脱氧胆酸-（14）C。在胆汁盐水解和胆汁酸色谱分离后，发现超过94%的放射性存在于脱氧胆酸中，其余则分散在几个未鉴定的小峰中，没有一个是胆酸。在该实验中，约85%的脱氧胆酸盐以甘氨酸共轭物形式排泄，13%以牛磺酸共轭物形式排泄。未发现可检测到的硫酸酯。这些结果表明，人体内脱氧胆酸的代谢仅涉及与甘氨酸和牛磺酸的再共轭，而不会再羟化为胆酸或硫酸化。
