β-肾上腺素能受体拮抗剂治疗特发性震颤
beta-Adrenoreceptor antagonists in essential tremor.
作者信息
Jefferson D, Jenner P, Marsden C D
出版信息
J Neurol Neurosurg Psychiatry. 1979 Oct;42(10):904-9. doi: 10.1136/jnnp.42.10.904.
Abstract
Three different beta-adrenoreceptor antagonists--propranolol, sotalol, and atenolol--were compared in a double-blind study with placebo in nine patients with essential tremor. All three drugs produced an equal reduction in standing pulse rate but atenolol was less effective in reducing tremor than propranolol and sotalol. These results suggest that the reduction in tremor produced by beta-adrenoreceptor antagonists is mediated by an effect on peripheral beta 2-adrenoreceptors.
摘要
在一项双盲研究中，对9名特发性震颤患者使用三种不同的β-肾上腺素能受体拮抗剂（普萘洛尔、索他洛尔和阿替洛尔）与安慰剂进行比较。所有三种药物使静息脉搏率同等降低，但阿替洛尔在减轻震颤方面比普萘洛尔和索他洛尔效果差。这些结果表明，β-肾上腺素能受体拮抗剂产生的震颤减轻是由对外周β2-肾上腺素能受体的作用介导的。
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