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A pharmacokinetic model to differentiate preabsorptive, gut epithelial, and hepatic first-pass metabolism.

作者信息

Colburn W A

出版信息

J Pharmacokinet Biopharm. 1979 Aug;7(4):407-15. doi: 10.1007/BF01062538.

DOI:10.1007/BF01062538
PMID:512846
Abstract

A combined perfusion/compartmental pharmacokinetic model has been developed to describe the time course of drugs that are subject to preabsorptive, intestinal epithelial, and hepatic first-pass metabolism. Equations are derived to estimate the fraction of the administered dose which is metabolized at each of the three sites and to establish the limits of the true absorption rate constant. The model is tested using literature data for phenacetin.

摘要

相似文献

1
A pharmacokinetic model to differentiate preabsorptive, gut epithelial, and hepatic first-pass metabolism.
J Pharmacokinet Biopharm. 1979 Aug;7(4):407-15. doi: 10.1007/BF01062538.
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Commentary: theoretical predictions of flow effects on intestinal and systemic availability in physiologically based pharmacokinetic intestine models: the traditional model, segregated flow model, and QGut model.述评：生理药代动力学肠道模型中对肠道和全身利用率的流动效应的理论预测：传统模型、分隔流动模型和 QGut 模型。
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[First-pass effect as a therapeutic problem].
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Investigation of the intestinal permeability and first-pass metabolism of drugs in cynomolgus monkeys using single-pass intestinal perfusion.应用单次肠灌流技术研究食蟹猴的肠道通透性和药物首过代谢。
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引用本文的文献

1
Development of quantitative structure-pharmacokinetic relationships.定量构效关系的发展。
Environ Health Perspect. 1985 Sep;61:295-306. doi: 10.1289/ehp.8561295.

本文引用的文献

1
Methotrexate pharmacokinetics.甲氨蝶呤的药代动力学。
J Pharm Sci. 1971 Aug;60(8):1128-33. doi: 10.1002/jps.2600600803.
2
Effect of parallel first-order loss from site of administration on calculated values for absorption rate constants.
J Pharm Sci. 1972 Jan;61(1):135-8. doi: 10.1002/jps.2600610133.
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Physiologically based pharmacokinetic model for digoxin distribution and elimination in the rat.地高辛在大鼠体内分布与消除的生理药代动力学模型
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Mathematical basis of point-area deconvolution method for determining in vivo input functions.用于确定体内输入函数的点面积反褶积法的数学基础。
J Pharm Sci. 1978 May;67(5):663-5. doi: 10.1002/jps.2600670524.
5
Pharmacokinetic model of presystemic metabolism.首过代谢的药代动力学模型。
Drug Metab Dispos. 1978 Mar-Apr;6(2):193-6.
6
Pharmacokinetics of 3,3',5,5'-tetrachlorobiphenyl in the male rat.
Drug Metab Dispos. 1977 Sep-Oct;5(5):444-50.
7
Effect of 3-methylcholanthrene pretreatment on the bioavailability of phenacetin in the rat.3-甲基胆蒽预处理对大鼠体内非那西丁生物利用度的影响。
Drug Metab Dispos. 1976 Jul-Aug;4(4):402-6.