修饰吲哚生物碱的细胞毒性。
Cytotoxicity of modified indole alkaloids.
作者信息
Kingston D G, Sami S M
出版信息
J Pharm Sci. 1979 Nov;68(11):1403-5. doi: 10.1002/jps.2600681117.
PMID:512888
Abstract
Indole alkaloids of the iboga series were structurally modified by incorporation of a 3,4-dimethoxybenzyl or -benzoyl unit so that they contained the N-O-O triangle required for antileukemic activity according to the triangulation hypothesis. The cytotoxicities of the modified alkaloids in the in vitro P-388 system were not significantly increased over the unmodified alkaloids, suggesting that the triangulation hypothesis does not apply in this series at least.
摘要
通过引入3,4-二甲氧基苄基或 - 苯甲酰基单元对伊博格系列的吲哚生物碱进行结构修饰，以使它们包含根据三角剖分假说具有抗白血病活性所需的N-O-O三角形。修饰后的生物碱在体外P-388系统中的细胞毒性相比未修饰的生物碱没有显著增加，这表明三角剖分假说至少在该系列中不适用。
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