营养不良儿童的肠道二肽水解酶活性
Intestinal dipeptide hydrolase activities in undernourished children.
作者信息
Kumar V, Ghai O P, Chase H P
出版信息
Arch Dis Child. 1971 Dec;46(250):801-4. doi: 10.1136/adc.46.250.801.
Abstract
Intestinal dipeptide hydrolase enzymes cleave dipeptides into amino acids. In 8 undernourished children with diarrhoea, mean intestinal mucosal glyclyl-proline hydrolase activity was reduced 40%, valyl-proline hydrolase activity 38%, and alkaline phosphatase activity 54%, as compared with 4 controls. The use of hydrolysed proteins or simple amino acid mixtures in the initial treatment of undernourished children is suggested.
摘要
肠道二肽水解酶可将二肽裂解为氨基酸。与4名对照儿童相比，8名营养不良腹泻儿童的肠道黏膜甘氨酰脯氨酸水解酶活性平均降低了40%，缬氨酰脯氨酸水解酶活性降低了38%，碱性磷酸酶活性降低了54%。建议在营养不良儿童的初始治疗中使用水解蛋白或简单氨基酸混合物。
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