大鼠脑中胆碱来源的研究。
Studies on the origin of choline in the brain of the rat.
作者信息
Ansell G B, Spanner S
出版信息
Biochem J. 1971 May;122(5):741-50. doi: 10.1042/bj1220741.
Abstract
- Labelled precursors of choline, namely ethanolamine, dimethylaminoethanol and methionine and also labelled choline itself were injected intraperitoneally into the adult female rat and the incorporation into lipids and water-soluble fractions was traced in liver, blood and brain. 2. No significant free choline was detected and no labelling of the phosphorylcholine of blood. There was, however, considerable labelling of the phosphorylcholine of brain and liver. 3. After intracerebral injection, [1,2-(14)C]dimethylaminoethanol was rapidly phosphorylated and converted into phosphatidyldimethylaminoethanol, presumably by the cytidine pathway. 4. In view of the pattern of labelling and the amount of phosphatidylcholine in the tissues examined, it seems highly likely that choline is transported to the brain by the blood in a lipid-bound form.
摘要
- 将胆碱的标记前体，即乙醇胺、二甲基氨基乙醇和蛋氨酸，以及标记的胆碱本身腹腔注射到成年雌性大鼠体内，并追踪其在肝脏、血液和大脑中掺入脂质和水溶性部分的情况。2. 未检测到明显的游离胆碱，血液中的磷酸胆碱也未被标记。然而，大脑和肝脏的磷酸胆碱有相当程度的标记。3. 脑内注射后，[1,2-(14)C]二甲基氨基乙醇迅速磷酸化并转化为磷脂酰二甲基氨基乙醇，推测是通过胞苷途径。4. 鉴于所检查组织中的标记模式和磷脂酰胆碱的含量，胆碱很可能以脂质结合的形式通过血液运输到大脑。
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本文引用的文献
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Phosphorylcholine in rat tissues.大鼠组织中的磷酰胆碱。
Biochem J. 1955 Jun;60(2):325-8. doi: 10.1042/bj0600325.
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STUDIES ON THE METHYLATION OF ETHANOLAMINE PHOSPHATIDES BY LIVER PREPARATIONS.肝脏制剂对乙醇胺磷脂甲基化作用的研究。
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RED-CELL AND PLASMA LIPIDS IN ACANTHOCYTOSIS.棘红细胞增多症中的红细胞和血浆脂质
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Biochem J. 1962 Sep;84(3):497-501. doi: 10.1042/bj0840497.
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Mono- and dimethylethanolamine isolated from rat-liver phospholipids.从大鼠肝脏磷脂中分离出的单甲基乙醇胺和二甲基乙醇胺。
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