发育中大鼠脑内髓鞘与其他膜之间的固醇交换
Exchange of sterols between myelin and other membranes of developing rat brain.
作者信息
Banik N L, Davison A N
出版信息
Biochem J. 1971 May;122(5):751-8. doi: 10.1042/bj1220751.
Abstract
- The effect of inhibition of cholesterol synthesis by a hypocholesterolaemic drug (AY-9944) was studied in rat brain during development. 2. At 2 weeks after administration of AY-9944 to young rats 7-dehydrocholesterol accounted for half the total sterol of myelin and other subcellular components. 3. At 4 weeks after injection of the drug 7-dehydrocholesterol had disappeared whereas the cholesterol content of myelin had increased by an equivalent amount. Our studies show that purified myelin has low 7-dehydrocholesterol reductase activity and suggest that 7-dehydrocholesterol is largely converted into cholesterol outside the myelin sheath. 4. Resultant cholesterol may be re-incorporated into myelin by an exchange process. 5. The metabolism of sterols in developing brain is discussed.
摘要
- 研究了一种降胆固醇药物（AY - 9944）抑制胆固醇合成对发育中大鼠脑的影响。2. 给幼鼠施用AY - 9944两周后，7 - 脱氢胆固醇占髓鞘和其他亚细胞成分总甾醇的一半。3. 注射该药物四周后，7 - 脱氢胆固醇消失，而髓鞘的胆固醇含量等量增加。我们的研究表明，纯化的髓鞘具有低7 - 脱氢胆固醇还原酶活性，并提示7 - 脱氢胆固醇主要在髓鞘外转化为胆固醇。4. 生成的胆固醇可能通过交换过程重新掺入髓鞘。5. 讨论了发育中脑内甾醇的代谢。
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