多胺对人原顶体蛋白酶向顶体蛋白酶转化的抑制作用。

Polyamine inhibition of the conversion of human proacrosin to acrosin.

作者信息

Parrish R F, Goodpasture J C, Zaneveld L J, Polakoski K L

出版信息

J Reprod Fertil. 1979 Sep;57(1):239-43. doi: 10.1530/jrf.0.0570239.

DOI:10.1530/jrf.0.0570239

Abstract

The conversion of human proacrosin to acrosin was inhibited by polyamines. The order of effectiveness was spermine greater than spermidine greater than cadaverine greater than putrescine greater than 1,3,-diaminopropane. These results are similar to those obtained for the conversion of boar proacrosin to acrosin. Unlike the effects on boar acrosin, however, polyamines did not affect the esterolytic activity of human acrosin but had a slight stimulatory effect on the proteolytic activity of human acrosin.

摘要

多胺可抑制人源前顶体蛋白酶向顶体蛋白酶的转化。其有效性顺序为：精胺＞亚精胺＞尸胺＞腐胺＞1,3 - 二氨基丙烷。这些结果与在公猪前顶体蛋白酶向顶体蛋白酶转化中所获得的结果相似。然而，与对公猪顶体蛋白酶的影响不同，多胺并不影响人源顶体蛋白酶的酯解活性，而是对人源顶体蛋白酶的蛋白水解活性有轻微的刺激作用。