Greenberg M I, Roberts J R, Krusz J C, Baskin S I
JACEP. 1979 Dec;8(12):500-3. doi: 10.1016/s0361-1124(79)80294-4.
This study was undertaken to determine if epinephrine administered endotracheally is as effective in treating anaphylactic shock as is intravenously administered epinephrine. An animal model of anaphylactic shock was produced in anesthetized dogs by the intravenous administration of histamine phosphate. Both the endotracheal and intravenous routes of epinephrine administration resulted in efficient and effective reversal of histamine-induced hypotension. At the doses employed, the intravenous administration of epinephrine resulted in the production of significantly (p less than 0.05) greater numbers of ventricular cardiac arrhythmias than did the endotracheal route of administration.
本研究旨在确定经气管内给予肾上腺素治疗过敏性休克是否与静脉注射肾上腺素同样有效。通过静脉注射磷酸组胺在麻醉犬身上建立过敏性休克动物模型。经气管内和静脉途径给予肾上腺素均能有效逆转组胺诱导的低血压。在所使用的剂量下，静脉注射肾上腺素比经气管内给药导致产生明显更多（p<0.05）的室性心律失常。
