Auld W H, Murdoch W R
Br Med J. 1971 Dec 25;4(5790):786-8. doi: 10.1136/bmj.4.5790.786.
A controlled clinical trial of a new diuretic-mefruside-is reported, in which it was compared with frusemide in 15 normal subjects and 15 patients with fluid retention. It was found to be an effective diuretic which, in the patients, produced a significantly greater excretion of water and electrolytes than an equal dose of frusemide. Its smooth prolonged action, maximal in the first 12 hours, made it of particular value for maintenance therapy. In a short-term trial on a further 15 hypertensive patients mefruside was shown to have a useful hypotensive action. The drug was well tolerated with minimal side effects.
报道了一种新型利尿剂——甲氯噻嗪的对照临床试验，该试验将其与速尿在15名正常受试者和15名有液体潴留的患者中进行了比较。结果发现它是一种有效的利尿剂，在患者中，与等量的速尿相比，它能显著增加水和电解质的排泄。其作用平稳且持续时间长，在最初12小时达到最大效果，这使其对维持治疗具有特殊价值。在另外15名高血压患者的短期试验中，甲氯噻嗪显示出有益的降压作用。该药物耐受性良好，副作用极小。
