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伴刀豆球蛋白A刺激的淋巴细胞在体外对靶细胞的破坏作用。

Target cell destruction in vitro by concanavalin A-stimulated lymphoid cells.

作者信息

Schwartz H J, Wilson F

出版信息

Am J Pathol. 1971 Aug;64(2):295-304.

PMID:5142268
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2047574/
Abstract

Guinea pig lymphoid cells obtained from lymph nodes and spleens of nonimmune animals are cytotoxic for mouse L-cell fibroblasts on incubation with concanavalin A. This effect is blocked by methyl-alpha-D-mannoside. The results indicate that this effect may be due to the release of a lymphotoxin by the concanavalin A-stimulated lymphocytes.

摘要

从非免疫动物的淋巴结和脾脏获得的豚鼠淋巴细胞，在与伴刀豆球蛋白A孵育时，对小鼠L细胞成纤维细胞具有细胞毒性。这种效应被α-D-甲基甘露糖苷阻断。结果表明，这种效应可能是由于伴刀豆球蛋白A刺激的淋巴细胞释放了一种淋巴毒素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b15/2047574/7ce75f8d3c1c/amjpathol00408-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b15/2047574/71d91e5bab4a/amjpathol00408-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b15/2047574/7ce75f8d3c1c/amjpathol00408-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b15/2047574/71d91e5bab4a/amjpathol00408-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b15/2047574/7ce75f8d3c1c/amjpathol00408-0074-a.jpg

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本文引用的文献

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PHYTOHAEMAGGLUTININ-INDUCED CYTOTOXIC ACTION OF NORMAL LYMPHOID CELLS ON CELLS IN TISSUE CULTURE.植物血凝素诱导的正常淋巴细胞对组织培养细胞的细胞毒作用
Nature. 1964 Aug 22;203:841-3. doi: 10.1038/203841a0.
2
Precipitin reactions between extracts of seeds of Canavalia ensiformis (Jack Bean) and normal and pathological serum proteins.刀豆（洋刀豆）种子提取物与正常及病理血清蛋白之间的沉淀素反应。
Vox Sang. 1963 May-Jun;8:348-55.
3
Cytotoxic effect of lymphocyte-antigen interaction in delayed hypersensitivity.迟发型超敏反应中淋巴细胞 - 抗原相互作用的细胞毒性效应。
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Immunology. 1976 Aug;31(2):303-11.
Science. 1967 Sep 1;157(3792):1060-2. doi: 10.1126/science.157.3792.1060.
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