Toh Y C
Br J Cancer. 1971 Sep;25(3):516-9. doi: 10.1038/bjc.1971.65.
Fifteen minutes after the intraperitoneal injection of (32)P labelled phosphate, normal adult male rats show a higher incorporation of isotope into their liver nuclear RNA than do females. A single injection of testosterone into neonatal female rats causes a higher uptake of (32)P in adult life, while a single injection of oestradiol into male neonates lowers the incorporation in adult life. Gonadectomy at 4 weeks of age has only a small effect on the subsequent incorporation of (32)P into nuclear RNA either in control rats or in rats injected with sex hormones immediately after birth, showing that this effect of liver metabolism is mainly determined by the hormanal pattern at about the time of birth. The possible relevance of this sex difference in RNA metabolism to the different sex incidence of spontaneous or induced liver cancer is discussed.
腹腔注射（32）P标记的磷酸盐15分钟后，正常成年雄性大鼠肝脏核RNA中同位素的掺入量高于雌性大鼠。新生雌性大鼠单次注射睾酮会导致成年后（32）P摄取量增加，而新生雄性大鼠单次注射雌二醇则会降低成年后的掺入量。4周龄时进行性腺切除对随后（32）P掺入对照大鼠或出生后立即注射性激素的大鼠的核RNA中只有很小的影响，这表明肝脏代谢的这种影响主要由出生时的激素模式决定。讨论了RNA代谢中这种性别差异与自发或诱发肝癌不同性别发生率的可能相关性。
