Alderson M R, Hamlin I, Staunton M D
Br J Cancer. 1971 Dec;25(4):646-56. doi: 10.1038/bjc.1971.80.
A retrospective detailed study of 272 cases of breast carcinoma treated by radical mastectomy was published by Hamlin (1968). An extended analysis of the material for 258 of these cases is now reported.Data for 21 prognostic factors from 258 patients have been subjected to multiple regression analysis to determine the independent effect and thus the relative importance of each factor. The findings confirm previous single factor analyses and demonstrate that nine of the factors are independently associated with survival.Mathematical manipulation of the information obtained in this analysis allowed a risk score to be allotted to each patient. Grouping of patients by the prediction scores is found in this series to be more closely related to survival than is clinical staging of the same patients.
哈姆林（1968年）发表了一项对272例接受根治性乳房切除术治疗的乳腺癌病例的回顾性详细研究。现报告对其中258例病例资料的进一步分析。对258例患者的21个预后因素数据进行了多元回归分析，以确定各因素的独立作用，从而确定每个因素的相对重要性。研究结果证实了先前的单因素分析，并表明其中9个因素与生存率独立相关。对该分析中获得的信息进行数学处理，可为每位患者分配一个风险评分。在本系列研究中发现，根据预测评分对患者进行分组与生存率的相关性比相同患者的临床分期更为密切。
