Berrino F, Musso M, Campobasso O
Br J Cancer. 1971 Dec;25(4):669-79. doi: 10.1038/bjc.1971.82.
The pathological features, particularly local extent, size, and nodal involvement, of 405 surgical specimens of human lung carcinomas were studied. A direct relationship was found between local extent and size of the tumour and between local extent and the incidence of lymph node metastasis, but not between tumour size and the incidence of lymph node metastasis. The survival rates in the 405 tumours were calculated with the actuarial method in relation to the 3 pathological factors: local extent, lymph node metastasis and tumour size showed a predictive value in prognosis of lung tumours. Their prognostic value, however, was much more meaningful when the three pathological factors were considered in relation to each other. As a matter of fact, the size of the tumour showed no predictive value when lymph node metastasis was present. On the ground of the mutual influence of the 3 factors in affecting prognosis a pathological stage-grouping of lung tumours has been suggested.
对405例人肺癌手术标本的病理特征，特别是局部范围、大小和淋巴结受累情况进行了研究。发现肿瘤的局部范围与大小之间以及局部范围与淋巴结转移发生率之间存在直接关系，但肿瘤大小与淋巴结转移发生率之间不存在这种关系。采用精算方法计算了这405例肿瘤的生存率，与三个病理因素相关：局部范围、淋巴结转移和肿瘤大小对肺肿瘤的预后具有预测价值。然而，当将这三个病理因素相互关联考虑时，它们的预后价值更有意义。事实上，当存在淋巴结转移时，肿瘤大小没有预测价值。基于这三个因素对预后的相互影响，提出了肺肿瘤的病理分期分组。
