Wilkes M M, Lu K H, Hopper B R, Yen S S
Neuroendocrinology. 1979;29(4):255-61. doi: 10.1159/000122930.
The incidence of senescent anovulation (constant estrus) in female rats increases sharply in the age interval 10--14 months. We have compared the neuroendocrine status of 12-month-old rats, which were still cycling, with that of 6-month-old rats in the reproductive prime. Norepinephrine content in the median eminence of the hypothalamus and circulating levels of FSh and androstenedione were significnatly higher in middle-aged rats (12 months old) than in young controls (6 months old). These increases were selective, in that ten other neuroendocrine parameters measured were unchanged. These results indicate that changes occur at multiple levels of the neuroendocrine system during the transitional phase prior to the onset of senescent anovulation.
雌性大鼠衰老性无排卵（持续发情）的发生率在10至14月龄期间急剧上升。我们比较了仍处于发情周期的12月龄大鼠与处于繁殖盛期的6月龄大鼠的神经内分泌状态。中年大鼠（12月龄）下丘脑正中隆起中的去甲肾上腺素含量以及促卵泡激素（FSh）和雄烯二酮的循环水平显著高于年轻对照组（6月龄）。这些升高具有选择性，因为所测量的其他十个神经内分泌参数未发生变化。这些结果表明，在衰老性无排卵开始前的过渡阶段，神经内分泌系统的多个层面发生了变化。
