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Effect of -3-thienylalanine on antibody synthesis. V. Immunosuppression in mice by short diet and drug treatments.-3-噻吩丙氨酸对抗体合成的影响。V. 短期饮食和药物处理对小鼠的免疫抑制作用。
Infect Immun. 1971 Sep;4(3):240-4. doi: 10.1128/iai.4.3.240-244.1971.
2
Effect of beta-3-Thienylalanine on Antibody Synthesis IV. Suppression of the Immune Response in Mice.β-3-噻吩丙氨酸对抗体合成的影响 IV. 对小鼠免疫反应的抑制作用。
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Effect of -3-thienylalanine on antibody synthesis. VII. Further studies on the inhibition of RNA synthesis.-3-噻吩丙氨酸对抗体合成的影响。VII. 关于RNA合成抑制的进一步研究。
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Immunosuppression in vitro by beta-3-thienylalanine.β-3-噻吩丙氨酸的体外免疫抑制作用
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本文引用的文献

1
Effect of beta-3-Thienylalanine on Antibody Synthesis IV. Suppression of the Immune Response in Mice.β-3-噻吩丙氨酸对抗体合成的影响 IV. 对小鼠免疫反应的抑制作用。
Infect Immun. 1971 Jun;3(6):810-4. doi: 10.1128/iai.3.6.810-814.1971.
2
THE HETEROGENEITY OF THE IMMUNE RESPONSE.免疫反应的异质性
Science. 1964 Jul 31;145(3631):457-64. doi: 10.1126/science.145.3631.457.
3
Effect of beta-thienylalanine on antibody synthesis. I. Preliminary in vitro and in vivo studies.β-噻吩丙氨酸对抗体合成的影响。I. 初步的体外和体内研究。
Proc Soc Exp Biol Med. 1960 Aug-Sep;104:562-5. doi: 10.3181/00379727-104-25908.
4
Effect of beta-3-thienylalanine and deoxypyridoxine on the growth of the Murphy-Sturm lymphosarcoma.β-3-噻吩丙氨酸和脱氧吡哆醇对墨菲-斯特姆淋巴肉瘤生长的影响。
Cancer Res. 1960 Nov;20:1530-7.
5
The acute effects of beta3 thienylalanine in the adult male albino rat; observations on nitrogen balance, antibody formation, and tumor growth.β3-噻吩丙氨酸对成年雄性白化大鼠的急性影响；对氮平衡、抗体形成和肿瘤生长的观察
AMA Arch Pathol. 1956 Jul;62(1):62-73.
6
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
7
Detection of cells producing 7S antibodies by the plaque technique.采用蚀斑技术检测产生7S抗体的细胞。
Nature. 1965 Nov 27;208(5013):858-9. doi: 10.1038/208858a0.
8
Use of an antiglobulin serum to detect cells producing antibody with low haemolytic efficiency.使用抗球蛋白血清检测产生溶血效率低的抗体的细胞。
Nature. 1965 Nov 27;208(5013):859-61. doi: 10.1038/208859a0.
9
Effect of beta-3-thienylalanine on antibody synthesis. 3. Inhibition of RNA and protein synthesis in immunized rat spleen cells.β-3-噻吩丙氨酸对抗体合成的影响。3. 对免疫大鼠脾细胞中RNA和蛋白质合成的抑制作用。
Proc Soc Exp Biol Med. 1969 Jul;131(3):895-9. doi: 10.3181/00379727-131-34004.

-3-噻吩丙氨酸对抗体合成的影响。V. 短期饮食和药物处理对小鼠的免疫抑制作用。

Effect of -3-thienylalanine on antibody synthesis. V. Immunosuppression in mice by short diet and drug treatments.

作者信息

Misefari A, La Via M F

出版信息

Infect Immun. 1971 Sep;4(3):240-4. doi: 10.1128/iai.4.3.240-244.1971.

DOI:10.1128/iai.4.3.240-244.1971
PMID:5154884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC416295/
Abstract

The analogue of phenylalanine, beta-3-thienylalanine, depresses severely the primary and secondary immune response to sheep erythrocytes in mice when administered for a few days immediately before and after each injection of antigen. For this immunosuppression to occur, animals must be maintained on a phenylalanine-free diet during the times of drug injection since dietary phenylalanine will restore anamnestic response. With these experimental conditions, the number of direct and indirect plaque-forming cells is greatly reduced during immune responses. The finding that marked immunosuppression can be obtained with a very short drug and diet treatment points to a potential usefullness of the analogue as a powerful immunosuppressant.

摘要

苯丙氨酸的类似物β-3-噻吩丙氨酸，在每次注射抗原前后几天给药时，会严重抑制小鼠对绵羊红细胞的初次和二次免疫反应。要发生这种免疫抑制，在药物注射期间动物必须维持无苯丙氨酸饮食，因为膳食苯丙氨酸会恢复记忆反应。在这些实验条件下，免疫反应期间直接和间接空斑形成细胞的数量会大大减少。通过非常短的药物和饮食治疗就能获得显著免疫抑制这一发现，表明该类似物作为一种强效免疫抑制剂具有潜在用途。