Coop R L, Angus K W, Sykes A R
Res Vet Sci. 1979 May;26(3):363-71.
Eight four-month-old sheep were infected daily for 90 days with 2500 Trichostrongylus vitrinus larvae. Infections were patent by week 3; mean faecal egg counts reached a peak of 645 epg at week 5, then subsequently declined. Mean worm burden at slaughter was 6100 (range 60--25,080). Two sheep had visible lesions in the small intestine at slaughter. In both sheep, numerous shallow red depressed areas extended for 5 to 7 metres distal to the pylorus while, in one, more extensive irregular depressed areas occupied the first 1.5 metres. Microtopographical examination and scanning electron microscopy showed that these affected areas were devoid of villi and contained numerous worms embedded in the mucosa. Histological examination revealed many similarities with the lesions caused by T colubriformis. Subtotal villous atrophy and crypt elongation were present in the intestines from five of the remaining six sheep, and in these the mucosa contained numerous mononuclear cells and intraepithelial globule leucocytes.
8只4月龄绵羊每天感染2500条玻璃细颈线虫幼虫，持续感染90天。感染在第3周时粪便中可检测到虫卵；平均粪便虫卵计数在第5周达到峰值，为645个/克粪便，随后下降。屠宰时平均虫负荷为6100条（范围为60 - 25,080条）。2只绵羊在屠宰时小肠有可见病变。在这2只绵羊中，幽门远端5至7米处有许多浅红色凹陷区域，而其中1只绵羊，更广泛的不规则凹陷区域占据了前1.5米。微观地形学检查和扫描电子显微镜显示，这些受影响区域没有绒毛，黏膜中有许多蠕虫嵌入。组织学检查发现与蛇形毛圆线虫引起的病变有许多相似之处。其余6只绵羊中有5只的肠道出现了部分绒毛萎缩和隐窝延长，并且在这些绵羊的黏膜中含有大量单核细胞和上皮内球形白细胞。
