McN-A-343对迷走神经刺激引起的心脏减慢的阻断作用。
Blocking effect of McN-A-343 on cardiac slowing produced by vagal stimulation.
作者信息
Chiba S, Hashimoto K, Kubota K, Sato S
出版信息
Br J Pharmacol. 1971 Nov;43(3):675-6. doi: 10.1111/j.1476-5381.1971.tb07198.x.
Abstract
The effect of McN-A-343 was studied by direct administration into the sinus node artery of dogs vagotomized at the mid-cervical level. McN-A-343 blocked sinus bradycardia caused by electrical stimulation of the right vagus, while bradycardia induced by administration of acetylcholine or nicotine into the sinus node artery was not modified.
摘要
通过直接将McN - A - 343注入颈中部切断迷走神经的犬的窦房结动脉，研究了其作用。McN - A - 343可阻断由电刺激右侧迷走神经引起的窦性心动过缓，而向窦房结动脉注射乙酰胆碱或尼古丁所诱发的心动过缓则未被改变。
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