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1
Blocking effect of McN-A-343 on cardiac slowing produced by vagal stimulation.McN-A-343对迷走神经刺激引起的心脏减慢的阻断作用。
Br J Pharmacol. 1971 Nov;43(3):675-6. doi: 10.1111/j.1476-5381.1971.tb07198.x.
2
Cardiac slowing effects of clonidine (ST-155) in dogs.可乐定（ST-155）对犬的心脏减慢作用。
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引用本文的文献

1
Effects of the muscarinic agonist McN-A-343 on the release by sympathetic nerve stimulation of (3H)-noradrenaline from rabbit isolated ear arteries and guinea-pig atria.毒蕈碱激动剂 McN - A - 343 对兔离体耳动脉和豚鼠心房交感神经刺激释放（3H）-去甲肾上腺素的影响。
Br J Pharmacol. 1974 May;51(1):29-34. doi: 10.1111/j.1476-5381.1974.tb09628.x.

本文引用的文献

1
An unusual type of sympathetic ganglionic stimulant.一种不寻常类型的交感神经节兴奋剂。
J Pharmacol Exp Ther. 1961 May;132:156-70.
2
Chronic extrinsic cardiac denervation by regional neural ablation. Description of the operation, verification of the denervation, and its effects on myocardial catecholamines.通过区域神经消融进行慢性心脏外源性去神经支配。手术描述、去神经支配的验证及其对心肌儿茶酚胺的影响。
Circ Res. 1961 Mar;9:275-81. doi: 10.1161/01.res.9.2.275.
3
The actions of McN-A-343, pilocarpine and acetyl-beta-methylcholine on sympathetic ganglion cells of the frog.McN-A-343、毛果芸香碱和乙酰-β-甲基胆碱对青蛙交感神经节细胞的作用。
J Pharmacol Exp Ther. 1965 Nov;150(2):216-9.
4
Excitation of the parasympathetic ganglia of the canine urinary bladder through a muscarinic mechanism.
J Pharmacol Exp Ther. 1971 Jan;176(1):93-100.
5
Effects of nicotine and dimethylphenylpiperazinium on the S-A node activity of dogs in situ.尼古丁和二甲基苯基哌嗪对犬在位窦房结活动的影响。
Tohoku J Exp Med. 1969 Dec;99(4):407-9. doi: 10.1620/tjem.99.407.
6
Pharmacologic isolation of sinoatrial activity from effects of neural excitation by use of tetrodotoxin.利用河豚毒素从神经兴奋效应中对窦房结活动进行药理学分离。
J Pharmacol Exp Ther. 1969 Nov;170(1):91-6.
7
Responses of the sino-atrial node to change in pressure in the sinus node artery.窦房结对窦房结动脉压力变化的反应。
Circ Res. 1967 Sep;21(3):297-304. doi: 10.1161/01.res.21.3.297.

McN-A-343对迷走神经刺激引起的心脏减慢的阻断作用。

Blocking effect of McN-A-343 on cardiac slowing produced by vagal stimulation.

作者信息

Chiba S, Hashimoto K, Kubota K, Sato S

出版信息

Br J Pharmacol. 1971 Nov;43(3):675-6. doi: 10.1111/j.1476-5381.1971.tb07198.x.

DOI:10.1111/j.1476-5381.1971.tb07198.x
PMID:5157729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1665803/
Abstract

The effect of McN-A-343 was studied by direct administration into the sinus node artery of dogs vagotomized at the mid-cervical level. McN-A-343 blocked sinus bradycardia caused by electrical stimulation of the right vagus, while bradycardia induced by administration of acetylcholine or nicotine into the sinus node artery was not modified.

摘要

通过直接将McN - A - 343注入颈中部切断迷走神经的犬的窦房结动脉，研究了其作用。McN - A - 343可阻断由电刺激右侧迷走神经引起的窦性心动过缓，而向窦房结动脉注射乙酰胆碱或尼古丁所诱发的心动过缓则未被改变。