环磷酰胺在人体中的药代动力学。
Pharmacokinetics of cyclophosphamide in man.
作者信息
Cohen J L, Jao J Y, Jusko W J
出版信息
Br J Pharmacol. 1971 Nov;43(3):677-80. doi: 10.1111/j.1476-5381.1971.tb07199.x.
Abstract
- The pharmacokinetics of cyclophosphamide were investigated in cancer patients. The data can be characterized by a two-compartment open model. The half life of the elimination phase of the drug ranged between 3 and 11 hours.2. Extensive tubular reabsorption of the drug resulted in the excretion of only a small percentage of the administered dose. The mean renal clearance was 10.7 ml/minute.3. The calculated fraction of the dose of drug which was metabolized averaged 88%.
摘要
在癌症患者中研究了环磷酰胺的药代动力学。数据可用二室开放模型表征。该药物消除相的半衰期在3至11小时之间。
药物广泛的肾小管重吸收导致仅排出给药剂量的一小部分。平均肾清除率为10.7毫升/分钟。
计算得出药物代谢剂量的平均比例为88%。
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