Beevers D G, Hamilton M, Harpur J E
Postgrad Med J. 1971 Oct;47(552):639-43. doi: 10.1136/pgmj.47.552.639.
Two hundred and twenty-seven cases of moderate to severe hypertension were treated with thiazide diuretics alone for periods of up to 12 years. In 80% the hypertension was adequately controlled without additional antihypertensive agents. Hypokalaemic alkalosis was common despite potassium supplements—but caused no symptoms. The incidence of diabetes and gout was low. It is concluded that thiazide diuretics provide excellent control of hypertension with very few side effects.
227例中重度高血压患者单独使用噻嗪类利尿剂治疗长达12年。80%的患者在未加用其他抗高血压药物的情况下,高血压得到了充分控制。尽管补充了钾,但低钾性碱中毒仍很常见——但未引起症状。糖尿病和痛风的发病率较低。得出的结论是,噻嗪类利尿剂能很好地控制高血压,且副作用极少。