长期口服利尿剂治疗的高血压患者的身体成分变化。
Body composition changes in hypertensive subjects on long-term oral diuretic therapy.
作者信息
Healy J J, McKenna T J, Canning B S, Brien T G, Duffy G J, Muldowney F P
出版信息
Br Med J. 1970 Mar 21;1(5698):716-9. doi: 10.1136/bmj.1.5698.716.
Abstract
Hypertensive patients were treated with either chlorthalidone or frusemide for periods of two to four months. Reduction in blood pressure was seen with chlorthalidone but not with frusemide. This hypotensive effect appeared to be independent of the natriuretic effect.A significant reduction in total exchangeable potassium (K(E)) was seen with both agents, but no patient showed adverse symptoms or signs. There was no alteration in maximal urinary concentration or acidification, or in intravenous glucose tolerance or plasma insulin. It is concluded that potassium depletion of this degree does not require replacement therapy on a routine basis in hypertensive patients.
摘要
高血压患者接受了双氢克尿噻或速尿治疗，为期两到四个月。双氢克尿噻可使血压降低，而速尿则不然。这种降压作用似乎与利钠作用无关。两种药物均可使可交换钾总量（K(E)）显著降低，但无一例患者出现不良症状或体征。最大尿浓缩或酸化、静脉葡萄糖耐量或血浆胰岛素均无变化。结论是，这种程度的钾缺乏在高血压患者中无需常规进行替代治疗。
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