Liubovich E N, Cherviak M N
Ukr Biokhim Zh (1978). 1979 Sep-Oct;51(5):463-6.
The content of lipids in rat erythrocyte membranes was studied with vitamin A deficiency, Guerin's carcinoma and with administration of significant doses of vitamin A. It is found that vitamin A deficiency decreases the content of phospholipid fractions: phosphatidyl ethanolamine, sphingomyelin, phosphatidyl serine. The content of phosphatidyl choline is unchanged. Under conditions of the experiment the content of cholesterol decreases. This dependence is lost when calculating per 1 g of protein. In erythrocytes of rats with Guerin's carcinoma the content of lipids increases. The character of the results is unchanged when calculating per 1 mg of protein. When administering 200.000 IU of vitamin A the content of the phospholipid and free cholesterol identified fractions lowers significantly.
研究了维生素A缺乏、接种格林氏癌以及给予大剂量维生素A时大鼠红细胞膜中的脂质含量。发现维生素A缺乏会降低磷脂组分的含量：磷脂酰乙醇胺、鞘磷脂、磷脂酰丝氨酸。磷脂酰胆碱的含量不变。在实验条件下，胆固醇含量降低。按每1克蛋白质计算时，这种相关性消失。在患有格林氏癌的大鼠红细胞中，脂质含量增加。按每1毫克蛋白质计算时，结果特征不变。给予200,000国际单位维生素A时，所鉴定的磷脂和游离胆固醇组分的含量显著降低。
