Georgiev P
Vet Med Nauki. 1979;16(2):47-51.
Studied was the activity of the serum enzymes LAP, CE, APh, SPh, and guanase as well as the isoenzymes of the unspecific esterases and APh in guinea pigs treated with potassium bichromate. Morphologically and histopathologically, an acute injury of the kidney parenchyma was found, being in close correlation with the size of lesions and these enzymes' activity. The activity of APh, SPh, and CE rose, and that of LAP and guanase did not change. These enzymes proved to form an appropriate constallation the changes in which could reflect the functional status of the kidneys and substantiate the differential diagnosis of liver and kidney diseases.
研究了重铬酸钾处理的豚鼠血清中亮氨酸氨基肽酶（LAP）、胆碱酯酶（CE）、酸性磷酸酶（APh）、碱性磷酸酶（SPh）和鸟嘌呤酶的活性，以及非特异性酯酶和酸性磷酸酶的同工酶活性。在形态学和组织病理学上，发现肾实质有急性损伤，这与损伤大小和这些酶的活性密切相关。酸性磷酸酶、碱性磷酸酶和胆碱酯酶的活性升高，而亮氨酸氨基肽酶和鸟嘌呤酶的活性未改变。这些酶形成了一种合适的组合，其变化可以反映肾脏的功能状态，并为肝肾疾病的鉴别诊断提供依据。
