Hoeprich P D, Finn P D
Appl Microbiol. 1971 Nov;22(5):781-3. doi: 10.1128/am.22.5.781-783.1971.
Antagonism or double zones of inhibition (or both) resulted when Staphylococcus aureus was exposed to fosfomycin in Brain Heart Infusion, tryptic/papaic digest of casein/soybean, and Mueller Hinton culture media; neither occurred with a totally defined, completely synthetic medium. The extent of antagonism was quantitated by determination of the absolute minimal inhibitory concentration of fosfomycin in each medium. By using the synthetic medium and inducers, the hexose-phosphate transport system appeared to be more important than the alpha-glycerophosphate transport system in providing ingress of fosfomycin into staphylococci.
当金黄色葡萄球菌在脑心浸液、胰蛋白酶/木瓜蛋白酶消化的酪蛋白/大豆培养基和穆勒-欣顿培养基中接触磷霉素时，会产生拮抗作用或双重抑菌圈（或两者皆有）；而在完全确定的完全合成培养基中则不会出现这种情况。通过测定每种培养基中磷霉素的绝对最低抑菌浓度来定量拮抗作用的程度。通过使用合成培养基和诱导剂，己糖磷酸转运系统在使磷霉素进入葡萄球菌方面似乎比α-甘油磷酸转运系统更重要。
