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[巴西日圆线虫含磷酰胆碱化合物注射对该寄生虫感染大鼠的影响]

[Effect of injection of a phosphorylcholine-containing compound from Nippostrongylus brasiliensis on the infestation of the rat by this parasite].

作者信息

Pery P, Petit A, Poulain J, Luffau G

出版信息

C R Acad Hebd Seances Acad Sci D. 1975 Jul 21;281(2-3):203-6.

PMID:51694
Abstract

Rats were injected intradermally with the purified phosphorycholine bearing component of the nematode Nippostrongylus brasiliensis. Eight days later they were experimentally infected with 1 X 10(3) infective larvae of the parasite. Compared to the non injected controls we showed a significant decrease in the number of adult worms able to be established in the small intestine. This protective effect seems to be due at least partly to a phenomenom being located between the skin and the lungs of the rats.

摘要

将巴西日圆线虫纯化的携带磷酸胆碱的成分皮内注射到大鼠体内。八天后,用1×10³条该寄生虫的感染性幼虫对它们进行实验性感染。与未注射的对照组相比,我们发现能够在小肠内定植的成虫数量显著减少。这种保护作用似乎至少部分归因于大鼠皮肤和肺部之间出现的一种现象。

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