Ivanova L, Nikolov R, Tsikalova P, Nikolova M
Acta Physiol Pharmacol Bulg. 1979;5(2):47-52.
The effect of As2 and Cinnarizin on cerebral circulation is studied on rabbits using the method of local cerebral rheography. Rheoencephalograms (REG) are recorded from the following brain structures; sensomotor cortex, substantia alba, poseterior hippocampus amygdala; nucleus caudatus and coliculus superior. Arterial blood pressure and ECG are studied simultaneously. Qualitative and quantitative analysis of the REG wave is made. Quantitative analysis involves the calculation of the following parameters: amplitude, anacrotic section of the curve and its relative part, spreading time and dicrotic index. The complex of REG-changes under the effect of the two drugs is very similar and suggests dilatation of the cerebral blood vessels. The difference is in the time of occurrence of the maximum effect: 5th min for As2 and 45th min for Cinnarizine.
采用局部脑血流图法，在兔身上研究了亚砷酸（As2）和桂利嗪对脑循环的影响。从以下脑结构记录脑血流图（REG）：感觉运动皮层、白质、后海马杏仁核、尾状核和上丘。同时研究动脉血压和心电图。对REG波进行定性和定量分析。定量分析包括计算以下参数：振幅、曲线的上升段及其相对部分、传播时间和重搏波指数。两种药物作用下REG变化的复合体非常相似，提示脑血管扩张。不同之处在于最大效应出现的时间：亚砷酸为第5分钟，桂利嗪为第45分钟。
