Blizzard R M
Birth Defects Orig Artic Ser. 1971 May;7(6):108-12.
An understanding of normal sexual development is essential to understanding abnormal sexual development. Normal differentiation of the bipotential external genitalia, reproductive ducts, and gonads are dependent upon the presence or absence of androgens from any source, the presence or absence of mullerian inhibiting factor from the fetal testes, and the number and type of sex chromosomes present respectively. Abnormal differentiation results from an imbalance of one or more of these factors or peripheral resistance to these factors.
了解正常性发育对于理解异常性发育至关重要。双潜能外生殖器、生殖管道和性腺的正常分化分别取决于任何来源雄激素的有无、胎儿睾丸中苗勒抑制因子的有无以及性染色体的数量和类型。异常分化是由这些因素中的一个或多个失衡或对这些因素的外周抵抗所致。
