Jackson C E, Block M A, Greenawald K A, Tashjian A H
Am J Hum Genet. 1979 Nov;31(6):704-10.
Comparisons are presented of the ages of onset of 20 cases of hereditary medullary carcinoma of the thyroid (MCT) and of 22 sporadic cases of this same type of cancer. These data are compatible with what might be expected by the two-mutational-event theory of the initiation of cancer postulated by Knudson. It had been previously postulated that C-cell hyperplasia of the thyroid was a premalignant change resulting from the first or genetic mutational event in the initiation of this type of cancer. The finding of C-cell hyperplasia in thyroid glands of each of the 10 patients with the hereditary condition and in none of the 10 sporadic patients is compatible with this theory. The C-cell hyperplasia is believed to be the expression of the genetic mutation, which requires a subsequent somatic mutation to transform the initially mutated cell into a cancer cell.
对20例遗传性甲状腺髓样癌（MCT）和22例散发性同类型癌症的发病年龄进行了比较。这些数据与Knudson提出的癌症起始的双突变事件理论所预期的情况相符。此前曾推测，甲状腺C细胞增生是这种类型癌症起始时第一个或基因性突变事件导致的癌前变化。在10例遗传性疾病患者的甲状腺中均发现了C细胞增生，而10例散发性患者中均未发现，这一发现与该理论相符。C细胞增生被认为是基因突变的表现，需要随后的体细胞突变才能将最初突变的细胞转化为癌细胞。
