Gladstien K, Shapiro L J, Spence M A
Am J Hum Genet. 1979 Nov;31(6):741-6.
We derive the conditional probabilities for estimating the sex ratio in families ascertained through affected males for the study of X-linked recessive diseases. These conditional probabilities correct for the fact that the probability that a family will be ascertained increases with the number of males in the family. Data from four published studies for X-linked ichthyosis vulgaris are analyzed, three having an excess of males and one having a highly statistically significant excess of males. It is not known if this difference in the two samples represents a biological difference between the two populations or an unrecognized ascertainment bias.
我们推导了通过患病男性来确定家庭中用于X连锁隐性疾病研究的性别比例估计的条件概率。这些条件概率校正了这样一个事实，即一个家庭被确定的概率会随着家庭中男性数量的增加而增加。对四项已发表的寻常型X连锁鱼鳞病研究数据进行了分析，其中三项研究中男性过多，一项研究中男性数量具有高度统计学显著的过量。尚不清楚这两个样本中的差异是代表了两个人群之间的生物学差异，还是一种未被认识到的确定偏倚。
