Obstbaum S A, Galin M A
Am J Ophthalmol. 1979 Dec;88(6):1017-9. doi: 10.1016/0002-9394(79)90408-2.
We studied the effect of timolol on post-operative intraocular pressures (IOPs) in a control and experimental group of 30 eyes, each in patients who had uncomplicated intracapsular cataract extractions, most with iris clip lenses. Closure of the eye in each case was with three 6-0 silk sutures preplaced in a morticed incision. Six control eyes had IOP increases of 6 mm Hg or more within 24 hours of surgery. One patient treated with timolol had an IOP increase of 6 mm Hg or more. The differences in IOP between the control and experimental groups were statistically significant at the .01 level. The pressure lowering ability of timolol appears to be prophylactic as well as therapeutic. It is well suited for pseudophakic eyes as pressure reduction is not associated with pupillary alterations.
我们在30只眼睛的对照组和实验组中研究了噻吗洛尔对术后眼压（IOP）的影响，这些眼睛均来自接受无并发症囊内白内障摘除术的患者，大多数患者植入了虹膜夹晶状体。每种情况下，眼睛均通过预先放置在榫槽切口内的三根6-0丝线缝合关闭。6只对照眼在手术后24小时内眼压升高6 mmHg或更多。一名接受噻吗洛尔治疗的患者眼压升高6 mmHg或更多。对照组和实验组之间的眼压差异在0.01水平上具有统计学意义。噻吗洛尔的降压能力似乎具有预防性和治疗性。它非常适合人工晶状体眼，因为眼压降低与瞳孔改变无关。
