Turpin G, Heshmati H M, Roger M, Cesselin E, Lagoguey M, Baulieu J L, de Gennes J L
Ann Endocrinol (Paris). 1979 Jul-Aug;40(4):425-6.
Cerebrospinal fluid (CSF) and serum concentrations of TSH, ACTH, FSH, LH, GH and PRL were measured simultaneously in 34 subjects divided into 3 groups: I-12 normal subjects (6 males and 6 females); II-12 prolactin adenomas (3 males and 9 females); III-5 empty sella syndromes, 3 hypothalamic disorders, 1 chromophobe adenoma, 1 pituitary dwarfism. It is concluded that: 1) pituitary hormones are the normal constituents of CSF but the level can be undetectable and in any case lower than the serum level. 2) there is a positive correlation between serum and CSF concentration of PRL when serum PRL is higher than 20 ng/ml, indicating that the CSF level is influenced by serum level. 3) in prolactin adenomas, only prolactin is elevated in the CSF. 4) there is no correlation between the high level of CSF-PRL and a suprasellar extension of the adenoma.
在34名受试者中同时测量了脑脊液（CSF）和血清中促甲状腺激素（TSH）、促肾上腺皮质激素（ACTH）、促卵泡激素（FSH）、促黄体生成素（LH）、生长激素（GH）和催乳素（PRL）的浓度，这些受试者分为3组：I组-12名正常受试者（6名男性和6名女性）；II组-12名催乳素腺瘤患者（3名男性和9名女性）；III组-5例空蝶鞍综合征、3例下丘脑疾病、1例嫌色细胞瘤、1例垂体性侏儒症。得出以下结论：1）垂体激素是脑脊液的正常成分，但水平可能检测不到，且无论如何都低于血清水平。2）当血清PRL高于20 ng/ml时，血清和脑脊液中PRL浓度呈正相关，表明脑脊液水平受血清水平影响。3）在催乳素腺瘤中，脑脊液中仅催乳素升高。4）脑脊液PRL高水平与腺瘤鞍上扩展之间无相关性。
