David M, Dorche C, Teyssier G, Cotte J, Jeune M
Ann Endocrinol (Paris). 1979 Jul-Aug;40(4):447-50.
Systematic screening for congenital hypothyroidism was started in Lyon in september 1976. This screening was coupled with PKU, using the same dried blood samples on filter paper obtained on the 5th day of life. TSH levels were determined by radioimmunoassay adapted for dried blood samples (Kit Abbott). In 24 months, 56 176 samples were analyzed. The critical level calling for control was successively raised from from 20 to 30, now 40 microUI/ml of serum. A high level of TSH was found in 307 children (0,55%). Pathological deliveries were found in most of these infants (neonatal injury, cesarean, section forceps or ocytocic perfusion, neonatal icterus) and a second or a third measurement showed normal TSH level. Congenital hypothyroidism, was found detected in 18 infants: 12 ectopic gland, 5 athyreosis and 1 dyshormonogenesis. Treatment was begun at a mean age of 38 days (29 to 50 days).
1976年9月，里昂开始了先天性甲状腺功能减退症的系统筛查。这项筛查与苯丙酮尿症筛查相结合，使用出生第5天采集的滤纸干血样。促甲状腺激素（TSH）水平通过适用于干血样的放射免疫分析法（雅培试剂盒）测定。在24个月内，共分析了56176份样本。需要复查的临界值先后从20微国际单位/毫升提高到30微国际单位/毫升，现在为40微国际单位/毫升血清。307名儿童（0.55%）的TSH水平较高。这些婴儿大多有难产情况（新生儿损伤、剖宫产、产钳助产或催产素灌注、新生儿黄疸），再次或第三次测量显示TSH水平正常。18名婴儿被检测出先天性甲状腺功能减退症：12例异位甲状腺、5例甲状腺缺如和1例激素合成障碍。治疗开始时的平均年龄为38天（29至50天）。
