Scott R F, Thomas W A, Lee W M, Reiner J M, Florentin R A
Atherosclerosis. 1979 Nov;34(3):291-301. doi: 10.1016/s0021-9150(79)80007-6.
In the abdominal aortas of young mash-fed swine, intimal cell masses (pads, cushions) are located predominantly away from blood vessel orifices. They are found scattered throughout the aorta but nevertheless have a definite pattern of distribution. In the distal one half of the abdominal aorta, they are more frequent in the ventral quandrant than in the dorsal or either lateral quadrant. In the proximal half, intimal cell masses are more frequent in the dorsal quadrant. When experimental atherosclerosis is induced in the abdominal aortas of young swine by either a hypercholesterolemic diet or by aortic ballooning followed by a hypercholesterolemic diet, the distribution of early lesions is similar. The lesions are found predominantly in quadrants where intimal cell masses were found to be most frequent in the control group of swine. The results suggest that most of the lesions, though not necessarily all, arose from pre-existing intimal cell masses beneath the aortic surface.
在以糊状饲料喂养的幼年猪的腹主动脉中，内膜细胞团块（斑块、垫层）主要位于远离血管开口处。它们散在于整个主动脉中，但仍有明确的分布模式。在腹主动脉的远端一半，它们在腹侧象限比在背侧或任何一侧象限更常见。在近端一半，内膜细胞团块在背侧象限更常见。当通过高胆固醇饮食或通过主动脉球囊扩张后再给予高胆固醇饮食在幼年猪的腹主动脉中诱发实验性动脉粥样硬化时，早期病变的分布是相似的。病变主要出现在对照组猪中内膜细胞团块最常见的象限。结果表明，大多数病变（尽管不一定是全部）起源于主动脉表面下方预先存在的内膜细胞团块。
