Gregson R L, Davey M J, Prentice D E
Br J Exp Pathol. 1979 Oct;60(5):471-82.
Single doses of antigen suspension (alum-precipitated canine serum proteins) were administered intratracheally to SPF rats. After periods of 1, 2 and 3 weeks rats were killed and their lungs examined histologically. After an initial macrophage and perivascular lymphoid reaction, dose-related increases were found in the amount of bronchus-associated lymphoid tissue (BALT) and in the amount of DNA within BALT cells, indicating increased cell division. Immunoglobulin-containing cells were demonstrated within BALT 3 weeks after the exposure to antigen. A prominent and extensive bronchial lympho-epithelium was seen overlying BALT follicles in antigen-treated rats, while in control animals the respiratory epithelium overlying BALT was predominantly normal ciliated epithelium. The significance of these findings is discussed in the light of the possible defensive role of BALT in cases of respiratory disease of man and animals.
将单剂量的抗原悬液（明矾沉淀的犬血清蛋白）经气管内注入无特定病原体（SPF）大鼠体内。在1周、2周和3周后处死大鼠，并对其肺部进行组织学检查。在最初的巨噬细胞和血管周围淋巴细胞反应之后，发现支气管相关淋巴组织（BALT）的数量以及BALT细胞内的DNA数量呈剂量相关增加，表明细胞分裂增加。在接触抗原3周后，在BALT内发现了含免疫球蛋白的细胞。在抗原处理的大鼠中，可见覆盖在BALT滤泡上的显著且广泛的支气管淋巴上皮，而在对照动物中，覆盖在BALT上的呼吸道上皮主要是正常的纤毛上皮。根据BALT在人和动物呼吸系统疾病中可能的防御作用，对这些发现的意义进行了讨论。
