Ikeda A, Maisel H, Waggoner D
J Embryol Exp Morphol. 1975 Apr;33(2):279-90.
The developmental pattern of appearance of a structural corneal antigenic determinant was studied by immunofluorescent methods. It was first detected in the primary corneal stroma at stage 23, and thereafter spread throughout the primary and secondary stroma. This antigen was absent from Bowman's membrane at its initial stage of development, suggesting that this membrane is a new structure in corneal morphogenesis, and not simply a modification of the primary stroma. This study also suggests that the antigenic determinant is a carbohydrate and is secreted by the corneal epithelial cells.
采用免疫荧光法研究了角膜结构抗原决定簇出现的发育模式。它在第23阶段首次在初级角膜基质中被检测到，随后扩散到初级和次级基质中。在其发育初期，Bowman膜中不存在这种抗原，这表明该膜是角膜形态发生中的一种新结构，而不仅仅是初级基质的一种修饰。这项研究还表明，抗原决定簇是一种碳水化合物，由角膜上皮细胞分泌。
