[Correlation between the immunological responsiveness to haptens and an increase in stem cell migration on immunization with hapten-carrier conjugates].

CBA and C57BL mice were immunized intraperitoneally with the conjugates 2,4-dinitrophenyl-bovine gamma-globulin, 2,4,6-trinitrophenyl-bovine serum albumin, diasotated p-aminobenzoic acid-bovine serum albumin, and sulfanylic acid-bovine serum albumin, whereupon migration of hemopoietic stem cells to the spleen was investigated. Immunization with the conjugates haptene--protein was shown in most cases to provoke an intensified migration of hemopoietic stem cells in mice highly responsive to the specific haptene, and at the same time to reduce, as a rule, the intensity of migration in mice of the poorly responsive genotype. It is concluded that the migration ability of stem cells seems likely to be connected with genetic determination of the immune response in mice of different genotypes.