Richards P, Brown C L
Lancet. 1975 Aug 2;2(7927):207-9. doi: 10.1016/s0140-6736(75)90675-3.
The blood-urea of a 43-year-old woman with normal renal function was 150 mg. per 100 ml. because she regularly consumed about 400 g. of protein daily. She had no symptoms of uraemia and her haemoglobin concentration was normal. Although she had a very large body-urea pool she degraded no more urea than healthy individuals on a normal diet. The failure of endogenous urea hydrolysis to increase in proportion to the blood-urea in renal failure has tentatively been ascribed to toxic effects of compounds retained with urea in renal failure; the findings in this azotaemic patient, who had neither signs nor symptoms of uraemia, cast doubt upon that explanation.
一名肾功能正常的43岁女性，其血尿素水平为每100毫升150毫克，原因是她每天经常摄入约400克蛋白质。她没有尿毒症症状，血红蛋白浓度正常。尽管她体内的尿素池非常大，但与正常饮食的健康个体相比，她分解的尿素并不更多。在肾衰竭时，内源性尿素水解未能与血尿素成比例增加，这一现象暂时归因于肾衰竭时与尿素一起潴留的化合物的毒性作用；而这名氮质血症患者既没有尿毒症的体征也没有症状，这一发现对此种解释提出了质疑。
