氯美噻唑对慢性酒精中毒患者血清促性腺激素和睾酮的影响。
The effect of chlormethiazole on serum gonadotrophins and testosterone in chronic alcoholics.
作者信息
Majumdar S K
出版信息
Curr Med Res Opin. 1979;6(3):213-6. doi: 10.1185/03007997909109425.
Serum gonadotrophins (LH and FSH) and testosterone concentrations were estimated by radioimmunoassay in 7 male chronic alcoholics on admission and following treatment with chlormethiazole for 6 days. Individual and mean values of serum LH and FSH were within normal limits both before and after treatment, but serum testosterone concentrations were found to be slightly higher than normal on both occasions. Chlormethiazole does not seem to have any effect on serum gonadotrophins or testosterone. It is further suggested that chlormethiazole does not interfere with the hypothalamic releasing factors for pituitary gonadotrophins and that it has no direct effect on testicular endocrine functions.
采用放射免疫分析法对7名男性慢性酒精中毒患者入院时及接受氯美噻唑治疗6天后的血清促性腺激素（促黄体生成素和促卵泡生成素）及睾酮浓度进行了测定。血清促黄体生成素和促卵泡生成素的个体值及平均值在治疗前后均在正常范围内，但两次测定时血清睾酮浓度均略高于正常水平。氯美噻唑似乎对血清促性腺激素或睾酮没有任何影响。进一步表明，氯美噻唑不干扰垂体促性腺激素的下丘脑释放因子，且对睾丸内分泌功能无直接影响。
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