Mikhaĭlova D, Astrug A, Staneva D, Nachev I
Eksp Med Morfol. 1979;18(4):229-34.
The authors investigated the pharmacokinetics of the pressor substance 5,8-dimetoxy-trans-2-/2-hydroxyethyl/-amino-3-hydroxy-1,2,3,4-tetrahydronaphthaline hydrochloride (1b), which possessed strong pressor action. Blood concentrations after venous administration in a dose of 1 mg/kg of body weight were determined by means of exctration spectrofluorometric method. The data complied with the biexponential equation, meeting the requirements of an open two-compartment model. There was a quick elimination of the substance from the central compartment, which correlated also with the data for quick disappearances of the effect on the arterial pressure.
作者研究了具有强烈升压作用的升压物质5,8 - 二甲氧基 - 反式 - 2 -（2 - 羟乙基）氨基 - 3 - 羟基 - 1,2,3,4 - 四氢萘盐酸盐（1b）的药代动力学。通过萃取荧光分光光度法测定静脉注射1mg/kg体重剂量后的血药浓度。数据符合双指数方程，符合开放二室模型的要求。该物质从中央室快速消除，这也与动脉压效应快速消失的数据相关。
